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Role of intermittent fasting and autophagy in healthy lifestyle.
Intermittent fasting, 16 hours fasting window and 8 hours eating window stimulate autophagy. Autophagy also known as chaperone-mediated autophagy is the process by which proteins damaged by free radicals are removed from the cell. This helps with overall cell longevity, increases insulin sensitivity and improves mitochondrial function. The 16 hour fasting window was defined according to the most effective interval of time for a minimum of 10 consecutive meals within a 24-hour period. For each individual, the Intermittent Fasting effect on autophagy was evaluated from week 3 to week 8. A variety of biomarkers were assessed over this period including serum insulin, glucose, and triglycerides as well as liver and skeletal muscle lipid content During fasting, autophagy increases, as a result of a longer starvation period and satiety signals. In addition to an increase in autophagy and lifespan extension, fasting also improves glucose homeostasis by normalizing blood glucose levels, prevent...
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